I'd be interested. There's been a few munchkin books centered around real tabletop, but mostly they're just tips and satire rather then actual stuff you could possibly get away with. Thief is actually a nerfed rogue, warrior is only a better fighter if you take advantage of the vagueness of his bonus feats, and cleric is just spontaneous variant of unearthed arcana. Monte Cook did munchkin way better with his pathfinder series... lol!
But this is Call of The Cthulhu. Not sure how munchkin it'd be less we were all more like Ash from Evil Dead and Ghostbusters instead of Rorschach and X-Files. XP But I'm in. I've never played the card game(s) before, are they simple enough to understand?