No prob. With Game of Thrones like I mostly meant power struggle and relationship drama in a fantasy like setting. I'm imagining some magic and strange creatures, since it is after all a Smallville game. Though if the rest of the players are violently opposed to it, I'll do it non magical.
My own thoughts is that you have a great big citystate similar to Baldur's Gate, Ankh Morpork, Sharn, Korvosa or Ptolus. There'd be some elves and dwarves and wizards. Though I imagine it to be rare.
But some world creation can be created through pathways. If someone suddenly comes up with Captain Hendricks a Airship Captain or the Demon Lord Grazt'kr'Ýr it will take the world in a certain direction. I don't want to limit anyone's creativity. In the same vein, somone could draw a line to someone with the text injured in the war, and it would cement a the fact that a war has happened or is currently going on. So some setting creation will come natural to the pathways system.
Hopefully we can come up with a great cast, while figuring out the setting. But as I said the only thing I had firmly in my mind was the big melting pot of a metropolis where every day is a wild adventure.