With a Gun and a Torch
The Old Gods are "alive", watching as their mortal servants perform unspeakable rites and rituals. Damned things lurk in the shadows, stalking the unwary with malicious intent. Vampires, werewolves, the undead, and numerous other creatures are found all over the world, preying on humanity for food or out of a sense of general sadism. While some of these things simply keep to themselves, and some fight against their brethren, most see mankind as nothing more than toys or food.
Most humans hide in fear from the supernatural, huddling behind locked doors each night, clutching their holy symbols and praying to whatever gods might be listening that something doesn't take a fancy to their throats. Some have turned traitor, serving and in some cases worshipping the monsters. And, every so often, there's a person who's well-equipped enough, well-trained enough, knowledgable enough, insane enough, or just plain lucky enough to hunt the supernatural for a living. Hunters usually travel extensively, protecting their fellow man from the supernatural with a gun in one hand and a torch in the other, all for a bag of coin.
