The campaign I have it mind wouldn't be the base traveler universes. More an amalgam of various popular or not so know science fiction IPs. For instance the pc's a Vulcan, Ewok, and a uplifted cyber dolphin, could be all stranded on the planet of Sakaar (marvel), having to odd jobs for a fella named Badger, stumbling into a Preditor hunt and trying to avoid a blue proto molecule infection..
Your basic player driven sandbox cluster frag with alot of GM story threads that the pcs will hopefully pull on.